Hispidulin suppresses tumor growth and metastasis in renal cell carcinoma by modulating ceramide-sphingosine 1-phosphate rheostat

Sphingosine 1-phosphate (S1P) rheostat is considered as a key signal that determines cell fate. This study aimed to report that hispidulin, a polyphenolic flavonoid, exerted anti-growth and anti-metastasis effects against renal cell carcinoma (RCC) by modulating the balance of ceramide-S1P. In vitro...

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Bibliographic Details
Published in:Am J Cancer Res
Main Authors: Gao, Ming-Quan, Gao, Hui, Han, Mei, Liu, Kai-Li, Peng, Jian-Jun, Han, Yan-Tao
Format: Artigo
Language:Inglês
Published: e-Century Publishing Corporation 2017
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5523031/
https://ncbi.nlm.nih.gov/pubmed/28744400
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