A Strategy for Dual Inhibition of the Proteasome and Fatty Acid Synthase with Belactosin C-Orlistat Hybrids

The proteasome, a validated cellular target for cancer, is central for maintaining cellular homeostasis, while fatty acid synthase (FAS), a novel target for numerous cancers, is responsible for palmitic acid biosynthesis. Perturbation of either enzymatic machine results in decreased proliferation an...

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Библиографические подробности
Опубликовано в: :Bioorg Med Chem
Главные авторы: Zhu, Mingzhao, Harshbarger, Wayne D., Robles, Omar, Krysiak, Joanna, Hull, Kenneth G., Cho, Sung Wook, Richardson, Robyn D., Yang, Yanyan, Garcia, Andres, Spiegelman, Lindsey, Ramirez, Bianca, Wilson, Christopher T., Yau, Ju Anne, Moore, James T., Walker, Caitlen B., Sacchettini, James C., Liu, Wenshe, Sieber, Stephan A., Smith, Jeffrey W., Romo, Daniel
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522751/
https://ncbi.nlm.nih.gov/pubmed/28236510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.01.020
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