A Strategy for Dual Inhibition of the Proteasome and Fatty Acid Synthase with Belactosin C-Orlistat Hybrids

The proteasome, a validated cellular target for cancer, is central for maintaining cellular homeostasis, while fatty acid synthase (FAS), a novel target for numerous cancers, is responsible for palmitic acid biosynthesis. Perturbation of either enzymatic machine results in decreased proliferation an...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Zhu, Mingzhao, Harshbarger, Wayne D., Robles, Omar, Krysiak, Joanna, Hull, Kenneth G., Cho, Sung Wook, Richardson, Robyn D., Yang, Yanyan, Garcia, Andres, Spiegelman, Lindsey, Ramirez, Bianca, Wilson, Christopher T., Yau, Ju Anne, Moore, James T., Walker, Caitlen B., Sacchettini, James C., Liu, Wenshe, Sieber, Stephan A., Smith, Jeffrey W., Romo, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522751/
https://ncbi.nlm.nih.gov/pubmed/28236510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.01.020
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