A Strategy for Dual Inhibition of the Proteasome and Fatty Acid Synthase with Belactosin C-Orlistat Hybrids

The proteasome, a validated cellular target for cancer, is central for maintaining cellular homeostasis, while fatty acid synthase (FAS), a novel target for numerous cancers, is responsible for palmitic acid biosynthesis. Perturbation of either enzymatic machine results in decreased proliferation an...

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Bibliografski detalji
Izdano u:Bioorg Med Chem
Glavni autori: Zhu, Mingzhao, Harshbarger, Wayne D., Robles, Omar, Krysiak, Joanna, Hull, Kenneth G., Cho, Sung Wook, Richardson, Robyn D., Yang, Yanyan, Garcia, Andres, Spiegelman, Lindsey, Ramirez, Bianca, Wilson, Christopher T., Yau, Ju Anne, Moore, James T., Walker, Caitlen B., Sacchettini, James C., Liu, Wenshe, Sieber, Stephan A., Smith, Jeffrey W., Romo, Daniel
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522751/
https://ncbi.nlm.nih.gov/pubmed/28236510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.01.020
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