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Mechanistically elucidating the in vitro safety and efficacy of a novel doxorubicin derivative
Doxorubicin is an effective anticancer drug; however, it is cardiotoxic and has poor oral bioavazilability. Quercetin is a plant-based flavonoid with inhibitory effects on P-glycoprotein (P-gp) and CYP3A4 and also antioxidant properties. To mitigate these therapeutic barriers, DoxQ, a novel derivati...
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| Publicado no: | Drug Deliv Transl Res |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5522622/ https://ncbi.nlm.nih.gov/pubmed/28462502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13346-017-0379-2 |
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