BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis

Myogenic differentiation proceeds through a highly coordinated cascade of gene activation that necessitates epigenomic changes in chromatin structure. Using a screen of small molecule epigenetic probes we identified three compounds which inhibited myogenic differentiation in C2C12 myoblasts; (+)-JQ1...

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Publicado no:Sci Rep
Main Authors: Roberts, Thomas C., Etxaniz, Usue, Dall’Agnese, Alessandra, Wu, Shwu-Yuan, Chiang, Cheng-Ming, Brennan, Paul E., Wood, Matthew J. A., Puri, Pier Lorenzo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522382/
https://ncbi.nlm.nih.gov/pubmed/28733670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06483-7
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