Synthetic lethality of glutaminolysis inhibition, autophagy inactivation and asparagine depletion in colon cancer

Cancer cells reprogram metabolism to coordinate their rapid growth. They addict on glutamine metabolism for adenosine triphosphate generation and macromolecule biosynthesis. In this study, we report that glutamine deprivation retarded cell growth and induced prosurvival autophagy. Autophagy inhibiti...

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Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Li, Jiaqiu, Song, Ping, Zhu, Liyuan, Aziz, Neelum, Zhou, Qiyin, Zhang, Yulong, Xu, Wenxia, Feng, Lifeng, Chen, Dingwei, Wang, Xian, Jin, Hongchuan
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2017
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522096/
https://ncbi.nlm.nih.gov/pubmed/28424408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16844
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