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Synthetic lethality of glutaminolysis inhibition, autophagy inactivation and asparagine depletion in colon cancer
Cancer cells reprogram metabolism to coordinate their rapid growth. They addict on glutamine metabolism for adenosine triphosphate generation and macromolecule biosynthesis. In this study, we report that glutamine deprivation retarded cell growth and induced prosurvival autophagy. Autophagy inhibiti...
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Publicado no: | Oncotarget |
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Main Authors: | , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Impact Journals LLC
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5522096/ https://ncbi.nlm.nih.gov/pubmed/28424408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16844 |
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