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Synthetic lethality of glutaminolysis inhibition, autophagy inactivation and asparagine depletion in colon cancer

Cancer cells reprogram metabolism to coordinate their rapid growth. They addict on glutamine metabolism for adenosine triphosphate generation and macromolecule biosynthesis. In this study, we report that glutamine deprivation retarded cell growth and induced prosurvival autophagy. Autophagy inhibiti...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Li, Jiaqiu, Song, Ping, Zhu, Liyuan, Aziz, Neelum, Zhou, Qiyin, Zhang, Yulong, Xu, Wenxia, Feng, Lifeng, Chen, Dingwei, Wang, Xian, Jin, Hongchuan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522096/
https://ncbi.nlm.nih.gov/pubmed/28424408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16844
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