Synthetic lethality of glutaminolysis inhibition, autophagy inactivation and asparagine depletion in colon cancer

Cancer cells reprogram metabolism to coordinate their rapid growth. They addict on glutamine metabolism for adenosine triphosphate generation and macromolecule biosynthesis. In this study, we report that glutamine deprivation retarded cell growth and induced prosurvival autophagy. Autophagy inhibiti...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Li, Jiaqiu, Song, Ping, Zhu, Liyuan, Aziz, Neelum, Zhou, Qiyin, Zhang, Yulong, Xu, Wenxia, Feng, Lifeng, Chen, Dingwei, Wang, Xian, Jin, Hongchuan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522096/
https://ncbi.nlm.nih.gov/pubmed/28424408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16844
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