ECIS technology reveals that monocytes isolated by CD14(+ve) selection mediate greater loss of BBB integrity than untouched monocytes, which occurs to a greater extent with IL-1β activated endothelium in comparison to TNFα

BACKGROUND: We have previously shown that TNFα and IL-1β differentially regulate the inflammatory phenotype of human brain endothelial cells (hCMVECs). In this regard, IL-1β treatment was considerably more potent than TNFα at increasing expression of inflammatory chemokines and leukocyte adhesion mo...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kho, Dan Ting, Johnson, Rebecca, Robilliard, Laverne, du Mez, Elyce, McIntosh, Julie, O’Carroll, Simon J., Angel, Catherine E., Graham, E. Scott
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5521748/
https://ncbi.nlm.nih.gov/pubmed/28732059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180267
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