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Filamin actin-binding and titin-binding fulfill distinct functions in Z-disc cohesion

Many proteins contribute to the contractile properties of muscles, most notably myosin thick filaments, which are anchored at the M-line, and actin thin filaments, which are anchored at the Z-discs that border each sarcomere. In humans, mutations in the actin-binding protein Filamin-C result in myop...

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Bibliografske podrobnosti
izdano v:PLoS Genet
Main Authors: González-Morales, Nicanor, Holenka, Tristan K., Schöck, Frieder
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5521747/
https://ncbi.nlm.nih.gov/pubmed/28732005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006880
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