Specific structural alteration of the influenza haemagglutinin by amantadine.

Amantadine hydrochloride specifically blocks the release of virus particles from H7 influenza virus infected cells. This appears to be the direct consequence of an amantadine induced change in the haemagglutinin (HA) to its low pH conformation. The effect is indirect and mediated via interaction of...

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Pubblicato in:	EMBO J
Autori principali:	Sugrue, R J, Bahadur, G, Zambon, M C, Hall-Smith, M, Douglas, A R, Hay, A J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC552095/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2209554/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1990.tb07555.x
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