Bilirubin neurotoxicity is associated with proteasome inhibition

The molecular mechanism underlying bilirubin neurotoxicity remains obscure. Ubiquitin–proteasome system-mediated proteolysis is pivotal to virtually all cellular processes and cell survival. Here we report for the first time that bilirubin at a clinically relevant elevated level impairs proteasomal...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Huang, Hongbiao, Guo, Mingxing, Liu, Ningning, Zhao, Chong, Chen, Haoyu, Wang, Xiaoli, Liao, Siyan, Zhou, Ping, Liao, Yuning, Chen, Xin, Lan, Xiaoying, Chen, Jinghong, Xu, Dacai, Li, Xiaofen, Shi, Xianping, Yu, Li, Nie, Yuqiang, Wang, Xuejun, Zhang, Chang-E, Liu, Jinbao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520929/
https://ncbi.nlm.nih.gov/pubmed/28617443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.274
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