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Cell fate conversion: a chromatin remodeling checkpoint revealed

In a new paper in Cell Research, Ji et al. find that transcription factor-instigated opening of chromatin, during cell reprogramming, can be sensed by the Baf60b-containing chromatin remodeling complex, which then activates the ATM-p53 pathway, leading to cell death. These findings from reprogrammin...

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Pubblicato in:Cell Res
Autore principale: Zaret, Kenneth S
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520856/
https://ncbi.nlm.nih.gov/pubmed/28361895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.44
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