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Cell fate conversion: a chromatin remodeling checkpoint revealed
In a new paper in Cell Research, Ji et al. find that transcription factor-instigated opening of chromatin, during cell reprogramming, can be sensed by the Baf60b-containing chromatin remodeling complex, which then activates the ATM-p53 pathway, leading to cell death. These findings from reprogrammin...
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| Published in: | Cell Res |
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| Main Author: | |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5520856/ https://ncbi.nlm.nih.gov/pubmed/28361895 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.44 |
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