Betulin exhibits anti-inflammatory activity in LPS-stimulated macrophages and endotoxin-shocked mice through an AMPK/AKT/Nrf2-dependent mechanism

Continued oxidative stress can lead to chronic inflammation, which in turn could mediate most chronic diseases including cancer. Nuclear factor erythroid 2-related factor (Nrf2), a critical transcriptional activator for antioxidative responses, has envolved to be an attractive drug target for the tr...

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Vydáno v:Cell Death Dis
Hlavní autoři: Ci, Xinxin, Zhou, Junfeng, Lv, Hongming, Yu, Qinlei, Peng, Liping, Hua, Shucheng
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520743/
https://ncbi.nlm.nih.gov/pubmed/28518138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.39
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