Chronically stressed or stress-preconditioned neurons fail to maintain stress granule assembly

Dysregulation of stress granules (SGs) and their resident proteins contributes to pathogenesis of a number of (neuro)degenerative diseases. Phosphorylation of eIF2α is an event integrating different types of cellular stress and it is required for SG assembly. Phosphorylated eIF2α (p-eIF2α) is upregu...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Shelkovnikova, Tatyana A, Dimasi, Pasquale, Kukharsky, Michail S, An, Haiyan, Quintiero, Annamaria, Schirmer, Claire, Buée, Luc, Galas, Marie-Christine, Buchman, Vladimir L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520719/
https://ncbi.nlm.nih.gov/pubmed/28492545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.199
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