All-trans retinoic acid and arsenic trioxide fail to derepress the monocytic differentiation driver Irf8 in acute promyelocytic leukemia cells

All-trans retinoic acid (ATRA) and/or arsenic trioxide (ATO) administration leads to granulocytic maturation and/or apoptosis of acute promyelocytic leukemia (APL) cells mainly by targeting promyelocytic leukemia/retinoic acid receptor alpha (PML/RARα). Yet, ~10–15% of APL patients are not cured by...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Liu, XiangZhen, Chen, Juan, Yu, ShanHe, Yan, Li, Guo, HeZhou, Dai, JianMin, Zhang, Wu, Zhu, Jiang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520717/
https://ncbi.nlm.nih.gov/pubmed/28492552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.197
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