MK2206 enhances the cytocidal effects of bufalin in multiple myeloma by inhibiting the AKT/mTOR pathway

Despite the development of promising cancer therapeutic drugs, multiple myeloma (MM) remains an incurable disease. Bufalin is a bufanolide steroid compound of the traditional Chinese medicine Chan Su that was previously shown to exert growth suppression effects on myeloma cell lines. Previous studie...

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Detalles Bibliográficos
Publicado en:Cell Death Dis
Main Authors: Xiang, Ru-Fang, Wang, Yan, Zhang, Nan, Xu, Wen-Bin, Cao, Yang, Tong, Jia, Li, Jun-min, Wu, Ying-Li, Yan, Hua
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520709/
https://ncbi.nlm.nih.gov/pubmed/28492559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.188
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