Inhibition of PTP1B disrupts cell–cell adhesion and induces anoikis in breast epithelial cells

Protein tyrosine phosphatase 1B (PTP1B) is a well-known inhibitor of insulin signaling pathways and inhibitors against PTP1B are being developed as promising drug candidates for treatment of obesity. PTP1B has also been linked to breast cancer both as a tumor suppressor and as an oncogene. Furthermo...

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Опубликовано в: :Cell Death Dis
Главные авторы: Hilmarsdottir, Bylgja, Briem, Eirikur, Halldorsson, Skarphedinn, Kricker, Jennifer, Ingthorsson, Sævar, Gustafsdottir, Sigrun, Mælandsmo, Gunhild M, Magnusson, Magnus K, Gudjonsson, Thorarinn
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2017
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520702/
https://ncbi.nlm.nih.gov/pubmed/28492548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.177
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