Inhibition of hepatitis B virus replication by N-hydroxyisoquinolinediones and related polyoxygenated heterocycles

We previously reported low sensitivity of the hepatitis B virus (HBV) ribonuclease H (RNaseH) enzyme to inhibition by N-hydroxyisoquinolinedione (HID) compounds. Subsequently, our biochemical RNaseH assay was found to have a high false negative rate for predicting HBV replication inhibition, leading...

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Pubblicato in:Antiviral Res
Autori principali: Edwards, Tiffany C., Lomonosova, Elena, Patel, Jenny A., Li, Qilan, Villa, Juan A., Gupta, Ankit K., Morrison, Lynda A., Bailly, Fabrice, Cotelle, Philippe, Giannakopoulou, Erofili, Zoidis, Grigoris, Tavis, John E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520537/
https://ncbi.nlm.nih.gov/pubmed/28450058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2017.04.012
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