Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies

BACKGROUND: Signet ring cell colorectal cancer (SRCCa) has a bleak prognosis. Employing molecular pathology techniques we investigated the potential of precision medicine in this disease. METHODS: Using test (n=26) and validation (n=18) cohorts, analysis of mutations, DNA methylation and transcripto...

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Veröffentlicht in:Br J Cancer
Hauptverfasser: Alvi, Muhammad A, Loughrey, Maurice B, Dunne, Philip, McQuaid, Stephen, Turkington, Richard, Fuchs, Marc-Aurel, McGready, Claire, Bingham, Victoria, Pang, Brendan, Moore, Wendy, Maxwell, Perry, Lawler, Mark, James, Jacqueline A, Murray, Graeme I, Wilson, Richard H, Salto-Tellez, Manuel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
Schlagworte:
Translational Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520517/
https://ncbi.nlm.nih.gov/pubmed/28595259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.168
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