Evolutionary genetic algorithm identifies IL2RB as a potential predictive biomarker for immune-checkpoint therapy in colorectal cancer

Identifying robust predictive biomarkers to stratify colorectal cancer (CRC) patients based on their response to immune-checkpoint therapy is an area of unmet clinical need. Our evolutionary algorithm Atlas Correlation Explorer (ACE) represents a novel approach for mining The Cancer Genome Atlas (TC...

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Veröffentlicht in:NAR Genom Bioinform
Hauptverfasser: Alderdice, Matthew, Craig, Stephanie G, Humphries, Matthew P, Gilmore, Alan, Johnston, Nicole, Bingham, Victoria, Coyle, Vicky, Senevirathne, Seedevi, Longley, Daniel B, Loughrey, Maurice B, McQuaid, Stephen, James, Jacqueline A, Salto-Tellez, Manuel, Lawler, Mark, McArt, Darragh G
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8057496/
https://ncbi.nlm.nih.gov/pubmed/33928242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nargab/lqab016
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