Extended RAS analysis and correlation with overall survival in advanced pancreatic cancer

BACKGROUND: Mutations in the KRAS gene can be detected in about 70–90% of pancreatic cancer (PC) cases. Whether these mutations have a prognostic or predictive value remains elusive. Furthermore, the clinical relevance of the extended RAS (KRAS+NRAS) mutational status is unclear in PC. METHODS: We p...

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Bibliographic Details
Published in:Br J Cancer
Main Authors: Haas, Michael, Ormanns, Steffen, Baechmann, Sibylle, Remold, Anna, Kruger, Stephan, Westphalen, Christoph B, Siveke, Jens T, Wenzel, Patrick, Schlitter, Anna Melissa, Esposito, Irene, Quietzsch, Detlef, Clemens, Michael R, Kettner, Erika, Laubender, Ruediger P, Jung, Andreas, Kirchner, Thomas, Boeck, Stefan, Heinemann, Volker
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
Subjects:
Genetics & Genomics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520094/
https://ncbi.nlm.nih.gov/pubmed/28449008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.115
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