Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy

BCL-2 family proteins are central regulators of mitochondrial apoptosis and validated anti-cancer targets. Using small cell lung cancer (SCLC) as a model, we demonstrated the presence of differential addiction of cancer cells to anti-apoptotic BCL-2, BCL-X(L) or MCL-1, which correlated with the resp...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Inoue-Yamauchi, Akane, Jeng, Paul S., Kim, Kwanghee, Chen, Hui-Chen, Han, Song, Ganesan, Yogesh Tengarai, Ishizawa, Kota, Jebiwott, Sylvia, Dong, Yiyu, Pietanza, Maria C., Hellmann, Matthew D., Kris, Mark G., Hsieh, James J., Cheng, Emily H.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520052/
https://ncbi.nlm.nih.gov/pubmed/28714472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms16078
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