An Interconnected Hierarchical Model of Cell Death Regulation by the BCL-2 Family

Multidomain proapoptotic BAX and BAK, once activated, permeabilize mitochondria to trigger apoptosis, whereas antiapoptotic BCL-2 members preserve mitochondrial integrity. The BH3-only molecules (BH3s) promote apoptosis by either activating BAX-BAK or inactivating antiapoptotic members. Here, we pre...

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Publicado no:Nat Cell Biol
Main Authors: Chen, Hui-Chen, Kanai, Masayuki, Inoue-Yamauchi, Akane, Tu, Ho-Chou, Huang, Yafen, Ren, Decheng, Kim, Hyungjin, Takeda, Shugaku, Reyna, Denis E., Chan, Po M., Ganesan, Yogesh Tengarai, Liao, Chung-Ping, Gavathiotis, Evripidis, Hsieh, James J., Cheng, Emily H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589531/
https://ncbi.nlm.nih.gov/pubmed/26344567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3236
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