Non-canonical NOTCH3 signalling limits tumour angiogenesis

Notch signalling is a causal determinant of cancer and efforts have been made to develop targeted therapies to inhibit the so-called canonical pathway. Here we describe an unexpected pro-apoptotic role of Notch3 in regulating tumour angiogenesis independently of the Notch canonical pathway. The Notc...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Lin, Shuheng, Negulescu, Ana, Bulusu, Sirisha, Gibert, Benjamin, Delcros, Jean-Guy, Ducarouge, Benjamin, Rama, Nicolas, Gadot, Nicolas, Treilleux, Isabelle, Saintigny, Pierre, Meurette, Olivier, Mehlen, Patrick
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2017
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520050/
https://ncbi.nlm.nih.gov/pubmed/28719575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms16074
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