Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis

MTBVAC is a live-attenuated Mycobacterium tuberculosis vaccine, currently under clinical development, that contains the major antigens ESAT6 and CFP10. These antigens are absent from the current tuberculosis vaccine, BCG. Here we compare the protection induced by BCG and MTBVAC in several mouse stra...

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Vydáno v:Nat Commun
Hlavní autoři: Aguilo, Nacho, Gonzalo-Asensio, Jesus, Alvarez-Arguedas, Samuel, Marinova, Dessislava, Gomez, Ana Belen, Uranga, Santiago, Spallek, Ralf, Singh, Mahavir, Audran, Regine, Spertini, François, Martin, Carlos
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519979/
https://ncbi.nlm.nih.gov/pubmed/28706226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms16085
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