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A CRISPR/Cas9 guidance RNA screen platform for HIV provirus disruption and HIV/AIDS gene therapy in astrocytes

HIV/AIDS remains a major health threat despite significant advances in the prevention and treatment of HIV infection. The major reason is the inability of existing treatments to eradicate the multiple HIV reservoirs in the human body, including astrocytes in the human brain. CRISPR/Cas9 system is an...

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Publicado en:Sci Rep
Main Authors: Huang, Zaohua, Nair, Madahavan
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519727/
https://ncbi.nlm.nih.gov/pubmed/28729655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06269-x
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