Distinct functional relevance of dynamic GTPase cysteine methylation in fission yeast

The final step in post-translational processing of Ras and Rho GTPases involves methylation of the prenylated cysteine residue by an isoprenylcysteine-O-carboxyl methyltransferase (ICMT). ICMT activity is essential for cell growth and development in higher eukaryotes, and inhibition of GTPase methyl...

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Published in:Sci Rep
Main Authors: Franco, Alejandro, Soto, Teresa, Martín-García, Rebeca, Madrid, Marisa, Vázquez-Marín, Beatriz, Vicente-Soler, Jero, Coll, Pedro M., Gacto, Mariano, Pérez, Pilar, Cansado, José
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519673/
https://ncbi.nlm.nih.gov/pubmed/28729673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06053-x
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