Anti-Tumor Activity and Immunotherapeutic Potential of a Bisphosphonate Prodrug

Bisphosphonates have benefits in breast cancer and multiple myeloma patients and have been used with adoptive immunotherapy with γδ T cells expressing Vγ2 Vδ2 TCRs. Although treatment with γδ T cells is safe, it has shown limited efficacy. Present bisphosphonates stimulate γδ T cells but were design...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Tanaka, Yoshimasa, Iwasaki, Masashi, Murata-Hirai, Kaoru, Matsumoto, Kenji, Hayashi, Kosuke, Okamura, Haruki, Sugie, Tomoharu, Minato, Nagahiro, Morita, Craig T., Toi, Masakazu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519590/
https://ncbi.nlm.nih.gov/pubmed/28729550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05553-0
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