A Novel α-Calcitonin Gene-Related Peptide Analogue Protects Against End-Organ Damage in Experimental Hypertension, Cardiac Hypertrophy, and Heart Failure

Research into the therapeutic potential of α-calcitonin gene–related peptide (α-CGRP) has been limited because of its peptide nature and short half-life. Here, we evaluate whether a novel potent and long-lasting (t(½) ≥7 hours) acylated α-CGRP analogue (αAnalogue) could alleviate and reverse cardiov...

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Detalhes bibliográficos
Publicado no:Circulation
Main Authors: Aubdool, Aisah A., Thakore, Pratish, Argunhan, Fulye, Smillie, Sarah-Jane, Schnelle, Moritz, Srivastava, Salil, Alawi, Khadija M., Wilde, Elena, Mitchell, Jennifer, Farrell-Dillon, Keith, Richards, Daniel A., Maltese, Giuseppe, Siow, Richard C., Nandi, Manasi, Clark, James E., Shah, Ajay M., Sams, Anette, Brain, Susan D.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2017
Assuntos:
Original Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519346/
https://ncbi.nlm.nih.gov/pubmed/28446517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.117.028388
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