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Llgl1 connects cell polarity with cell-cell adhesion in embryonic neural stem cells
Malformations of cerebral cortex (MCC) are devastating developmental disorders. We report here that mice with embryonic neural stem cell-specific deletion of Llgl1 (Nestin-Cre/Llgl1(fl/fl)), a mammalian ortholog of Drosophila cell polarity gene lgl, exhibit MCC resembling severe periventricular hete...
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Publicado no: | Dev Cell |
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Main Authors: | , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5519327/ https://ncbi.nlm.nih.gov/pubmed/28552558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.05.002 |
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