Sequencing of DICER1 in sarcomas identifies biallelic somatic DICER1 mutations in an adult-onset embryonal rhabdomyosarcoma

BACKGROUND: Sarcomas are rare and heterogeneous cancers. We assessed the contribution of DICER1 mutations to sarcoma development. METHODS: The coding region of DICER1 was sequenced in 67 sarcomas using a custom Fluidigm Access Array. The RNase III domains were Sanger sequenced in six additional sarc...

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Dades bibliogràfiques
Publicat a:Br J Cancer
Autors principals: de Kock, Leanne, Rivera, Barbara, Revil, Timothée, Thorner, Paul, Goudie, Catherine, Bouron-Dal Soglio, Dorothée, Choong, Catherine S, Priest, John R, van Diest, Paul J, Tanboon, Jantima, Wagner, Anja, Ragoussis, Jiannis, Choong, Peter FM, Foulkes, William D
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
Matèries:
Genetics & Genomics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518865/
https://ncbi.nlm.nih.gov/pubmed/28524158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.147
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