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Crystal structures, absolute configurations and molecular docking studies of naftopidil enantiomers as α(1D)-adrenoceptor antagonists
Chiral drug naftopidil (NAF), a specific α(1D)-adrenoceptor (AR) antagonist for the treatment of benign prostatic hyperplasia, was used in racemic form for several decades. Our recent work declared that NAF enantiomers showed the same antagonistic effects on the α(1D)-AR, but the binding mechanism o...
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| Udgivet i: | Acta Pharm Sin B |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5518653/ https://ncbi.nlm.nih.gov/pubmed/28752036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2017.04.011 |
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