APOL1 variants change C-terminal conformational dynamics and binding to SNARE protein VAMP8

APOL1 variants in African populations mediate resistance to trypanosomal infection but increase risk for kidney diseases through unknown mechanisms. APOL1 is expressed in glomerular podocytes and does not vary with underlying kidney disease diagnoses or APOL1 genotypes, suggesting that the kidney di...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Madhavan, Sethu M., O’Toole, John F., Konieczkowski, Martha, Barisoni, Laura, Thomas, David B., Ganesan, Santhi, Bruggeman, Leslie A., Buck, Matthias, Sedor, John R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518555/
https://ncbi.nlm.nih.gov/pubmed/28724794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92581
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