Mechanisms of action and rationale for the use of checkpoint inhibitors in cancer

The large family of costimulatory molecules plays a crucial role in regulation of the immune response. These molecules modulate TCR signalling via phosphorylation cascades. Some of the coinhibitory members of this family, such as PD-1 and CTLA-4, already constitute approved targets in cancer therapy...

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Detalles Bibliográficos
Publicado en:ESMO Open
Autores principales: Granier, Clemence, De Guillebon, Eleonore, Blanc, Charlotte, Roussel, Helene, Badoual, Cecile, Colin, Elia, Saldmann, Antonin, Gey, Alain, Oudard, Stephane, Tartour, Eric
Formato: Artigo
Lenguaje:Inglês
Publicado: BMJ Publishing Group 2017
Materias:
Review
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518304/
https://ncbi.nlm.nih.gov/pubmed/28761757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/esmoopen-2017-000213
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