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Autophagy determines efficiency of liver‐directed gene therapy with adeno‐associated viral vectors
Use of adeno‐associated viral (AAV) vectors for liver‐directed gene therapy has shown considerable success, particularly in patients with severe hemophilia B. However, the high vector doses required to reach therapeutic levels of transgene expression caused liver inflammation in some patients that s...
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| Veröffentlicht in: | Hepatology |
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5518300/ https://ncbi.nlm.nih.gov/pubmed/28318036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29176 |
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