Hypoxia‐inducible factor 1‐alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl‐4‐hydroxylase 2

Osteogenic–angiogenic coupling is promoted by the hypoxia‐inducible factor 1‐alpha (HIF‐1α) transcription factor, provoking interest in HIF activation as a therapeutic strategy to improve osteoblast mineralization and treat pathological osteolysis. However, HIF also enhances the bone‐resorbing activ...

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Detalhes bibliográficos
Publicado no:J Pathol
Main Authors: Hulley, Philippa A, Bishop, Tammie, Vernet, Aude, Schneider, Jurgen E, Edwards, James R, Athanasou, Nick A, Knowles, Helen J
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2017
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518186/
https://ncbi.nlm.nih.gov/pubmed/28418093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4906
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