Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib

The mixed lineage kinase ZAK is a key regulator of the MAPK pathway mediating cell survival and inflammatory response. ZAK is targeted by several clinically approved kinase inhibitors, and inhibition of ZAK has been reported to protect from doxorubicin-induced cardiomyopathy. On the other hand, unin...

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Detaylı Bibliyografya
Yayımlandı:ACS Chem Biol
Asıl Yazarlar: Mathea, Sebastian, Abdul Azeez, Kamal R., Salah, Eidarus, Tallant, Cynthia, Wolfreys, Finn, Konietzny, Rebecca, Fischer, Roman, Lou, Hua Jane, Brennan, Paul E., Schnapp, Gisela, Pautsch, Alexander, Kessler, Benedikt M., Turk, Benjamin E., Knapp, Stefan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518171/
https://ncbi.nlm.nih.gov/pubmed/26999302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00043
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