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Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib
The mixed lineage kinase ZAK is a key regulator of the MAPK pathway mediating cell survival and inflammatory response. ZAK is targeted by several clinically approved kinase inhibitors, and inhibition of ZAK has been reported to protect from doxorubicin-induced cardiomyopathy. On the other hand, unin...
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Veröffentlicht in: | ACS Chem Biol |
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Hauptverfasser: | , , , , , , , , , , , , , |
Format: | Artigo |
Sprache: | Inglês |
Veröffentlicht: |
2016
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Schlagworte: | |
Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5518171/ https://ncbi.nlm.nih.gov/pubmed/26999302 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00043 |
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