Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib

The mixed lineage kinase ZAK is a key regulator of the MAPK pathway mediating cell survival and inflammatory response. ZAK is targeted by several clinically approved kinase inhibitors, and inhibition of ZAK has been reported to protect from doxorubicin-induced cardiomyopathy. On the other hand, unin...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:ACS Chem Biol
Egile Nagusiak: Mathea, Sebastian, Abdul Azeez, Kamal R., Salah, Eidarus, Tallant, Cynthia, Wolfreys, Finn, Konietzny, Rebecca, Fischer, Roman, Lou, Hua Jane, Brennan, Paul E., Schnapp, Gisela, Pautsch, Alexander, Kessler, Benedikt M., Turk, Benjamin E., Knapp, Stefan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518171/
https://ncbi.nlm.nih.gov/pubmed/26999302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00043
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