Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib

The mixed lineage kinase ZAK is a key regulator of the MAPK pathway mediating cell survival and inflammatory response. ZAK is targeted by several clinically approved kinase inhibitors, and inhibition of ZAK has been reported to protect from doxorubicin-induced cardiomyopathy. On the other hand, unin...

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Vydáno v:ACS Chem Biol
Hlavní autoři: Mathea, Sebastian, Abdul Azeez, Kamal R., Salah, Eidarus, Tallant, Cynthia, Wolfreys, Finn, Konietzny, Rebecca, Fischer, Roman, Lou, Hua Jane, Brennan, Paul E., Schnapp, Gisela, Pautsch, Alexander, Kessler, Benedikt M., Turk, Benjamin E., Knapp, Stefan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518171/
https://ncbi.nlm.nih.gov/pubmed/26999302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00043
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