Inactivation of human alpha-globin gene expression by a de novo deletion located upstream of the alpha-globin gene cluster.

Synthesis of normal human hemoglobin A, alpha 2 beta 2, is based upon balanced expression of genes in the alpha-globin gene cluster on chromosome 16 and the beta-globin gene cluster on chromosome 11. Full levels of erythroid-specific activation of the beta-globin cluster depend on sequences located...

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Main Authors: Liebhaber, S A, Griese, E U, Weiss, I, Cash, F E, Ayyub, H, Higgs, D R, Horst, J
Format: Artigo
Jezik:Inglês
Izdano: 1990
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC55179/
https://ncbi.nlm.nih.gov/pubmed/1701260
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