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Gene expression reversal toward pre-adult levels in the aging human brain and age-related loss of cellular identity

It was previously reported that mRNA expression levels in the prefrontal cortex at old age start to resemble pre-adult levels. Such expression reversals could imply loss of cellular identity in the aging brain, and provide a link between aging-related molecular changes and functional decline. Here w...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Dönertaş, Handan Melike, İzgi, Hamit, Kamacıoğlu, Altuğ, He, Zhisong, Khaitovich, Philipp, Somel, Mehmet
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5517654/
https://ncbi.nlm.nih.gov/pubmed/28724976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05927-4
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