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The chemical evolution of oligonucleotide therapies of clinical utility

After nearly 40 years of development, oligonucleotide therapeutics are nearing meaningful clinical productivity. One of the key advantages of oligonucleotide drugs is that their delivery and potency properties are derived primarily from the chemical structure of the oligonucleotide, while their targ...

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Detalhes bibliográficos
Publicado no:Nat Biotechnol
Main Authors: Khvorova, Anastasia, Watts, Jonathan K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5517098/
https://ncbi.nlm.nih.gov/pubmed/28244990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3765
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