Combined small-molecule inhibition accelerates the derivation of functional, early-born, cortical neurons from human pluripotent stem cells

Considerable progress has been made in converting human pluripotent stem cells (hPSCs) into functional neurons. However, the protracted timing of human neuron specification and functional maturation remains a key challenge that hampers the routine application of hPSC-derived lineages in disease mode...

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Publicado en:Nat Biotechnol
Main Authors: Qi, Yuchen, Zhang, Xin-Jun, Renier, Nicolas, Wu, Zhuhao, Atkin, Talia, Sun, Ziyi, Ozair, M. Zeeshan, Tchieu, Jason, Zimmer, Bastian, Fattahi, Faranak, Ganat, Yosif, Azevedo, Ricardo, Zeltner, Nadja, Brivanlou, Ali H., Karayiorgou, Maria, Gogos, Joseph, Tomishima, Mark, Tessier-Lavigne, Marc, Shi, Song-Hai, Studer, Lorenz
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516899/
https://ncbi.nlm.nih.gov/pubmed/28112759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3777
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