The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.

We have analyzed t(1;14)(p32;q11) chromosome translocations from two patients with T cell acute lymphocytic leukemia. The chromosome 1 breakpoints of these patients lie within a kilobasepair of each other, and thus define a genetic locus (designated tal) involved in T cell oncogenesis. Moreover, we...

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Dades bibliogràfiques
Publicat a:EMBO J
Autors principals: Chen, Q, Cheng, J T, Tasi, L H, Schneider, N, Buchanan, G, Carroll, A, Crist, W, Ozanne, B, Siciliano, M J, Baer, R
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 1990
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC551682/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2303035/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1990.tb08126.x
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