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Biology and Clinical Relevance of Acute Myeloid Leukemia Stem Cells

Evidence for the cancer stem cell model was first demonstrated in xenotransplanted blood and bone marrow samples from patients with acute myeloid leukemia (AML) almost two decades ago, supporting the concept that a rare clonal and mutated leukemic stem cell (LSC) population is sufficient to drive le...

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Bibliographic Details
Published in:Semin Hematol
Main Authors: Reinisch, Andreas, Chan, Steven M., Thomas, Daniel, Majeti, Ravindra
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516648/
https://ncbi.nlm.nih.gov/pubmed/26111462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.seminhematol.2015.03.008
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