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Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells
OBJECTIVE: Determine mechanisms responsible for enhanced statin efficacy in a novel statin combination we name STOX (STatin–OXysterol). METHODS: Ovarian cancer cell lines were treated with combinations of statins and oxysterols. Cell viability was determined by a modified MTT assay. Apoptosis was ev...
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| Опубликовано в: : | Gynecol Oncol |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5516475/ https://ncbi.nlm.nih.gov/pubmed/25134999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2014.08.015 |
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