Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells

OBJECTIVE: Determine mechanisms responsible for enhanced statin efficacy in a novel statin combination we name STOX (STatin–OXysterol). METHODS: Ovarian cancer cell lines were treated with combinations of statins and oxysterols. Cell viability was determined by a modified MTT assay. Apoptosis was ev...

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Udgivet i:Gynecol Oncol
Main Authors: Casella, Cinzia, Miller, Daniel H., Lynch, Kerry, Brodsky, Alexander S.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516475/
https://ncbi.nlm.nih.gov/pubmed/25134999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2014.08.015
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